Intradermal and virosomal influenza vaccines for preventing influenza hospitalization in the elderly during the 2011-2012 influenza season: a comparative effectiveness study using the Valencia health care information system.
Identifieur interne : 000217 ( Main/Exploration ); précédent : 000216; suivant : 000218Intradermal and virosomal influenza vaccines for preventing influenza hospitalization in the elderly during the 2011-2012 influenza season: a comparative effectiveness study using the Valencia health care information system.
Auteurs : J. Puig-Barberà [Espagne] ; A. Natividad-Sancho [Espagne] ; J. Calabuig-Pérez [Espagne] ; J A Lluch-Rodrigo [Espagne] ; E. Pastor-Villalba [Espagne] ; S. Martínez-Úbeda [Espagne] ; J. Díez-Domingo [Espagne]Source :
- Vaccine [ 1873-2518 ] ; 2014.
Descripteurs français
- KwdFr :
- Espagne (MeSH), Femelle (MeSH), Grippe humaine (prévention et contrôle), Hospitalisation (statistiques et données numériques), Humains (MeSH), Modèles des risques proportionnels (MeSH), Mâle (MeSH), Sujet âgé (MeSH), Sujet âgé de 80 ans ou plus (MeSH), Vaccins antigrippaux (classification), Vaccins antigrippaux (usage thérapeutique), Vaccins à virosomes (usage thérapeutique), Études rétrospectives (MeSH).
- MESH :
- classification : Vaccins antigrippaux.
- prévention et contrôle : Grippe humaine.
- statistiques et données numériques : Hospitalisation.
- usage thérapeutique : Vaccins antigrippaux, Vaccins à virosomes.
- Espagne, Femelle, Humains, Modèles des risques proportionnels, Mâle, Sujet âgé, Sujet âgé de 80 ans ou plus, Études rétrospectives.
- Wicri :
- geographic : Espagne.
English descriptors
- KwdEn :
- Aged (MeSH), Aged, 80 and over (MeSH), Female (MeSH), Hospitalization (statistics & numerical data), Humans (MeSH), Influenza Vaccines (classification), Influenza Vaccines (therapeutic use), Influenza, Human (prevention & control), Male (MeSH), Proportional Hazards Models (MeSH), Retrospective Studies (MeSH), Spain (MeSH), Vaccines, Virosome (therapeutic use).
- MESH :
- chemical , classification : Influenza Vaccines.
- chemical , therapeutic use : Vaccines, Virosome.
- geographic : Spain.
- prevention & control : Influenza, Human.
- statistics & numerical data : Hospitalization.
- chemical , therapeutic use : Influenza Vaccines.
- Aged, Aged, 80 and over, Female, Humans, Male, Proportional Hazards Models, Retrospective Studies.
Abstract
BACKGROUND
The use of intradermal vaccination or virosomal vaccines could increase protection against influenza among the vulnerable population of older adults. Studies assessing the comparative effectiveness of these two influenza vaccine types in this age group are lacking.
METHODS
We conducted a retrospective cohort study to estimate the comparative effectiveness of intradermal seasonal trivalent-influenza vaccine (TIV) delivered by a microneedle injection system and a virosomal-TIV intramuscularly delivered for prevention of influenza hospitalization in non-institutionalized adults aged ≥65 years. We obtained administrative data on immunization status and influenza hospitalization for the 2011-2012 influenza season, and used Cox regression models to assess comparative effectiveness. We estimated crude and adjusted (age, sex, comorbidity, pharmaceutical claims, recent pneumococcal vaccination and number of hospitalizations for all causes other than influenza between the previous and current influenza seasons) hazard ratios (HR).
RESULTS
Overall, 164,021 vaccinated subjects were evaluated. There were 127 hospitalizations for influenza among 62,058 subjects, contributing 914,740 person-weeks at risk in the virosomal-TIV group, and 133 hospitalizations for influenza among 101,963 subjects, contributing 1,504,570 person-weeks at risk in the intradermal-TIV group. The crude HR of intradermal-TIV relative to virosomal-TIV was 0.64 (95% confidence interval (CI): 0.50-0.81), and the adjusted Cox estimated HR was 0.67 (95% CI: 0.52-0.85).
CONCLUSIONS
During the 2011-2012 influenza season the risk of hospitalization for influenza was reduced by 33% in non-institutionalized elderly adults who were vaccinated with intradermal-TIV compared with virosomal-TIV.
DOI: 10.1016/j.vaccine.2014.07.095
PubMed: 25131737
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Díez-Domingo</name><affiliation wicri:level="1"><nlm:affiliation>Área de Investigación en Vacunas, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)-Salud Pública, Valencia, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Área de Investigación en Vacunas, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)-Salud Pública, Valencia</wicri:regionArea><wicri:noRegion>Valencia</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:25131737</idno><idno type="pmid">25131737</idno><idno type="doi">10.1016/j.vaccine.2014.07.095</idno><idno type="wicri:Area/Main/Corpus">00199</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">00199</idno><idno type="wicri:Area/Main/Curation">000199</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000199</idno><idno type="wicri:Area/Main/Exploration">000199</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Intradermal and virosomal influenza vaccines for preventing influenza hospitalization in the elderly during the 2011-2012 influenza season: a comparative effectiveness study using the Valencia health care information system.</title><author><name sortKey="Puig Barbera, J" sort="Puig Barbera, J" uniqKey="Puig Barbera J" first="J" last="Puig-Barberà">J. Puig-Barberà</name><affiliation wicri:level="1"><nlm:affiliation>Área de Investigación en Vacunas, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)-Salud Pública, Valencia, Spain. Electronic address: puig_joa@gva.es.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Área de Investigación en Vacunas, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)-Salud Pública, Valencia</wicri:regionArea><wicri:noRegion>Valencia</wicri:noRegion></affiliation></author><author><name sortKey="Natividad Sancho, A" sort="Natividad Sancho, A" uniqKey="Natividad Sancho A" first="A" last="Natividad-Sancho">A. Natividad-Sancho</name><affiliation wicri:level="1"><nlm:affiliation>Área de Investigación en Vacunas, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)-Salud Pública, Valencia, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Área de Investigación en Vacunas, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)-Salud Pública, Valencia</wicri:regionArea><wicri:noRegion>Valencia</wicri:noRegion></affiliation></author><author><name sortKey="Calabuig Perez, J" sort="Calabuig Perez, J" uniqKey="Calabuig Perez J" first="J" last="Calabuig-Pérez">J. Calabuig-Pérez</name><affiliation wicri:level="1"><nlm:affiliation>Servicio de Análisis de Sistemas de Información Sanitaria, Agencia Valenciana de Salud, Valencia, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Servicio de Análisis de Sistemas de Información Sanitaria, Agencia Valenciana de Salud, Valencia</wicri:regionArea><wicri:noRegion>Valencia</wicri:noRegion></affiliation></author><author><name sortKey="Lluch Rodrigo, J A" sort="Lluch Rodrigo, J A" uniqKey="Lluch Rodrigo J" first="J A" last="Lluch-Rodrigo">J A Lluch-Rodrigo</name><affiliation wicri:level="1"><nlm:affiliation>Servicio de Salud Infantil y de la Mujer, Dirección General de Salud Pública, Valencia, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Servicio de Salud Infantil y de la Mujer, Dirección General de Salud Pública, Valencia</wicri:regionArea><wicri:noRegion>Valencia</wicri:noRegion></affiliation></author><author><name sortKey="Pastor Villalba, E" sort="Pastor Villalba, E" uniqKey="Pastor Villalba E" first="E" last="Pastor-Villalba">E. Pastor-Villalba</name><affiliation wicri:level="1"><nlm:affiliation>Servicio de Salud Infantil y de la Mujer, Dirección General de Salud Pública, Valencia, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Servicio de Salud Infantil y de la Mujer, Dirección General de Salud Pública, Valencia</wicri:regionArea><wicri:noRegion>Valencia</wicri:noRegion></affiliation></author><author><name sortKey="Martinez Beda, S" sort="Martinez Beda, S" uniqKey="Martinez Beda S" first="S" last="Martínez-Úbeda">S. Martínez-Úbeda</name><affiliation wicri:level="1"><nlm:affiliation>Área de Investigación en Vacunas, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)-Salud Pública, Valencia, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Área de Investigación en Vacunas, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)-Salud Pública, Valencia</wicri:regionArea><wicri:noRegion>Valencia</wicri:noRegion></affiliation></author><author><name sortKey="Diez Domingo, J" sort="Diez Domingo, J" uniqKey="Diez Domingo J" first="J" last="Díez-Domingo">J. Díez-Domingo</name><affiliation wicri:level="1"><nlm:affiliation>Área de Investigación en Vacunas, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)-Salud Pública, Valencia, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Área de Investigación en Vacunas, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)-Salud Pública, Valencia</wicri:regionArea><wicri:noRegion>Valencia</wicri:noRegion></affiliation></author></analytic><series><title level="j">Vaccine</title><idno type="eISSN">1873-2518</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged (MeSH)</term><term>Aged, 80 and over (MeSH)</term><term>Female (MeSH)</term><term>Hospitalization (statistics & numerical data)</term><term>Humans (MeSH)</term><term>Influenza Vaccines (classification)</term><term>Influenza Vaccines (therapeutic use)</term><term>Influenza, Human (prevention & control)</term><term>Male (MeSH)</term><term>Proportional Hazards Models (MeSH)</term><term>Retrospective Studies (MeSH)</term><term>Spain (MeSH)</term><term>Vaccines, Virosome (therapeutic use)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Espagne (MeSH)</term><term>Femelle (MeSH)</term><term>Grippe humaine (prévention et contrôle)</term><term>Hospitalisation (statistiques et données numériques)</term><term>Humains (MeSH)</term><term>Modèles des risques proportionnels (MeSH)</term><term>Mâle (MeSH)</term><term>Sujet âgé (MeSH)</term><term>Sujet âgé de 80 ans ou plus (MeSH)</term><term>Vaccins antigrippaux (classification)</term><term>Vaccins antigrippaux (usage thérapeutique)</term><term>Vaccins à virosomes (usage thérapeutique)</term><term>Études rétrospectives (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="classification" xml:lang="en"><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Vaccines, Virosome</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Spain</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="fr"><term>Vaccins antigrippaux</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="prévention et contrôle" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Hospitalization</term></keywords><keywords scheme="MESH" qualifier="statistiques et données numériques" xml:lang="fr"><term>Hospitalisation</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Vaccins antigrippaux</term><term>Vaccins à virosomes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Humans</term><term>Male</term><term>Proportional Hazards Models</term><term>Retrospective Studies</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Espagne</term><term>Femelle</term><term>Humains</term><term>Modèles des risques proportionnels</term><term>Mâle</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Études rétrospectives</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Espagne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>The use of intradermal vaccination or virosomal vaccines could increase protection against influenza among the vulnerable population of older adults. Studies assessing the comparative effectiveness of these two influenza vaccine types in this age group are lacking.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>We conducted a retrospective cohort study to estimate the comparative effectiveness of intradermal seasonal trivalent-influenza vaccine (TIV) delivered by a microneedle injection system and a virosomal-TIV intramuscularly delivered for prevention of influenza hospitalization in non-institutionalized adults aged ≥65 years. We obtained administrative data on immunization status and influenza hospitalization for the 2011-2012 influenza season, and used Cox regression models to assess comparative effectiveness. We estimated crude and adjusted (age, sex, comorbidity, pharmaceutical claims, recent pneumococcal vaccination and number of hospitalizations for all causes other than influenza between the previous and current influenza seasons) hazard ratios (HR).</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Overall, 164,021 vaccinated subjects were evaluated. There were 127 hospitalizations for influenza among 62,058 subjects, contributing 914,740 person-weeks at risk in the virosomal-TIV group, and 133 hospitalizations for influenza among 101,963 subjects, contributing 1,504,570 person-weeks at risk in the intradermal-TIV group. The crude HR of intradermal-TIV relative to virosomal-TIV was 0.64 (95% confidence interval (CI): 0.50-0.81), and the adjusted Cox estimated HR was 0.67 (95% CI: 0.52-0.85).</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>During the 2011-2012 influenza season the risk of hospitalization for influenza was reduced by 33% in non-institutionalized elderly adults who were vaccinated with intradermal-TIV compared with virosomal-TIV.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25131737</PMID><DateCompleted><Year>2015</Year><Month>04</Month><Day>03</Day></DateCompleted><DateRevised><Year>2014</Year><Month>09</Month><Day>08</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-2518</ISSN><JournalIssue CitedMedium="Internet"><Volume>32</Volume><Issue>42</Issue><PubDate><Year>2014</Year><Month>Sep</Month><Day>22</Day></PubDate></JournalIssue><Title>Vaccine</Title><ISOAbbreviation>Vaccine</ISOAbbreviation></Journal><ArticleTitle>Intradermal and virosomal influenza vaccines for preventing influenza hospitalization in the elderly during the 2011-2012 influenza season: a comparative effectiveness study using the Valencia health care information system.</ArticleTitle><Pagination><MedlinePgn>5447-54</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.vaccine.2014.07.095</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0264-410X(14)01077-9</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The use of intradermal vaccination or virosomal vaccines could increase protection against influenza among the vulnerable population of older adults. Studies assessing the comparative effectiveness of these two influenza vaccine types in this age group are lacking.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We conducted a retrospective cohort study to estimate the comparative effectiveness of intradermal seasonal trivalent-influenza vaccine (TIV) delivered by a microneedle injection system and a virosomal-TIV intramuscularly delivered for prevention of influenza hospitalization in non-institutionalized adults aged ≥65 years. We obtained administrative data on immunization status and influenza hospitalization for the 2011-2012 influenza season, and used Cox regression models to assess comparative effectiveness. We estimated crude and adjusted (age, sex, comorbidity, pharmaceutical claims, recent pneumococcal vaccination and number of hospitalizations for all causes other than influenza between the previous and current influenza seasons) hazard ratios (HR).</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Overall, 164,021 vaccinated subjects were evaluated. There were 127 hospitalizations for influenza among 62,058 subjects, contributing 914,740 person-weeks at risk in the virosomal-TIV group, and 133 hospitalizations for influenza among 101,963 subjects, contributing 1,504,570 person-weeks at risk in the intradermal-TIV group. The crude HR of intradermal-TIV relative to virosomal-TIV was 0.64 (95% confidence interval (CI): 0.50-0.81), and the adjusted Cox estimated HR was 0.67 (95% CI: 0.52-0.85).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">During the 2011-2012 influenza season the risk of hospitalization for influenza was reduced by 33% in non-institutionalized elderly adults who were vaccinated with intradermal-TIV compared with virosomal-TIV.</AbstractText><CopyrightInformation>Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Puig-Barberà</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Área de Investigación en Vacunas, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)-Salud Pública, Valencia, Spain. Electronic address: puig_joa@gva.es.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Natividad-Sancho</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Área de Investigación en Vacunas, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)-Salud Pública, Valencia, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Calabuig-Pérez</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Servicio de Análisis de Sistemas de Información Sanitaria, Agencia Valenciana de Salud, Valencia, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lluch-Rodrigo</LastName><ForeName>J A</ForeName><Initials>JA</Initials><AffiliationInfo><Affiliation>Servicio de Salud Infantil y de la Mujer, Dirección General de Salud Pública, Valencia, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pastor-Villalba</LastName><ForeName>E</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Servicio de Salud Infantil y de la Mujer, Dirección General de Salud Pública, Valencia, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martínez-Úbeda</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Área de Investigación en Vacunas, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)-Salud Pública, Valencia, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Díez-Domingo</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Área de Investigación en Vacunas, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)-Salud Pública, Valencia, Spain.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>08</Month><Day>12</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Vaccine</MedlineTA><NlmUniqueID>8406899</NlmUniqueID><ISSNLinking>0264-410X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007252">Influenza Vaccines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D022721">Vaccines, Virosome</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006760" MajorTopicYN="N">Hospitalization</DescriptorName><QualifierName UI="Q000706" MajorTopicYN="N">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007252" MajorTopicYN="N">Influenza Vaccines</DescriptorName><QualifierName UI="Q000145" MajorTopicYN="N">classification</QualifierName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016016" MajorTopicYN="N">Proportional Hazards Models</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013030" MajorTopicYN="N" Type="Geographic">Spain</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D022721" MajorTopicYN="N">Vaccines, Virosome</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Aged</Keyword><Keyword MajorTopicYN="N">Cohort studies</Keyword><Keyword MajorTopicYN="N">Comparative effectiveness research</Keyword><Keyword MajorTopicYN="N">Hospitalization</Keyword><Keyword MajorTopicYN="N">Influenza vaccines</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>02</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2014</Year><Month>06</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>07</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>8</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>8</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>4</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25131737</ArticleId><ArticleId IdType="pii">S0264-410X(14)01077-9</ArticleId><ArticleId IdType="doi">10.1016/j.vaccine.2014.07.095</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Espagne</li></country></list><tree><country name="Espagne"><noRegion><name sortKey="Puig Barbera, J" sort="Puig Barbera, J" uniqKey="Puig Barbera J" first="J" last="Puig-Barberà">J. Puig-Barberà</name></noRegion><name sortKey="Calabuig Perez, J" sort="Calabuig Perez, J" uniqKey="Calabuig Perez J" first="J" last="Calabuig-Pérez">J. Calabuig-Pérez</name><name sortKey="Diez Domingo, J" sort="Diez Domingo, J" uniqKey="Diez Domingo J" first="J" last="Díez-Domingo">J. Díez-Domingo</name><name sortKey="Lluch Rodrigo, J A" sort="Lluch Rodrigo, J A" uniqKey="Lluch Rodrigo J" first="J A" last="Lluch-Rodrigo">J A Lluch-Rodrigo</name><name sortKey="Martinez Beda, S" sort="Martinez Beda, S" uniqKey="Martinez Beda S" first="S" last="Martínez-Úbeda">S. Martínez-Úbeda</name><name sortKey="Natividad Sancho, A" sort="Natividad Sancho, A" uniqKey="Natividad Sancho A" first="A" last="Natividad-Sancho">A. Natividad-Sancho</name><name sortKey="Pastor Villalba, E" sort="Pastor Villalba, E" uniqKey="Pastor Villalba E" first="E" last="Pastor-Villalba">E. Pastor-Villalba</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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